机械工程学院

Tianlong Zhang received a bachelor's degree in engineering and master's degree in engineering from Jilin University, China in 2014 and 2017, respectively. He was a cotutelle PhD candidate in Division of Materials Science at Nara Institute of Science and Technology (NAIST), Japan and School of Engineering at Macquarie University, Australia. He worked as a a lecturer in Jiangsu University of Science and Technology (JUST) in China from September, 2023 to July, 2024. He is currently an associate professor at JUST in China. His research interests include bone mechanics, passive microfluidics, cell mechanics, cancer metastasis and laser processing.

My research interests include bone mechanics, passive microfluidics, cell mechanics, cancer metastasis and laser processing.

Bone Mechanics

Bone mechanics is the study of the mechanical properties and behavior of bones under various loads and stresses. It investigates how bones resist deformation, maintain strength, and adapt to mechanical forces. This field combines biomechanics, material science, and physiology to understand bone structure, fracture mechanics, and remodeling processes. Applications include orthopedic implant design and treatments for osteoporosis.

Passive Microfluidics

Passive microfluidics focuses on controlling the flow and behavior of fluids in microchannels without external forces like pumps or electric fields. It relies on capillary action, gravity, surface tension, and channel geometry for fluid manipulation. Passive microfluidic devices are cost-effective and energy-efficient, often used in lab-on-a-chip systems for applications such as diagnostics, chemical analysis, and environmental monitoring.

Cell Mechanics

Cell mechanics studies the mechanical properties and responses of cells, including their stiffness, adhesion, and deformation under external forces. It plays a crucial role in understanding cellular functions such as migration, division, and differentiation. Insights into cell mechanics are essential for research on disease progression, particularly in cancer, where changes in mechanical properties can indicate metastasis.

Cancer Metastasis

Cancer metastasis is the process by which cancer cells spread from the primary tumor to distant parts of the body, forming secondary tumors. This involves detachment from the tumor, invasion into surrounding tissues, entry into the bloodstream or lymphatic system, and colonization at a new site. Metastasis is a leading cause of cancer mortality, and its study integrates cell biology, genetics, and biomechanics.

Laser Processing

Laser processing involves using high-intensity laser beams to modify materials through cutting, welding, engraving, micromachining, or surface treatment. It is widely used in industries due to its precision, non-contact nature, and ability to work with diverse materials. Applications include microfabrication for electronics, medical devices, and advanced manufacturing techniques like femtosecond laser micromachining.

Projects

#1 Tianlong Zhang, Yalikun Yaxiaer, Chaoying Fang, Kazunori Okano, Sohei Yamada, Ryohei Yasukuni, Yoichiroh Hosokawa. The Femtosecond Laser-processed Pattern on Glass Substrate for Focusing Sub-micrometer Particles in Fluid (PI, 25000 ¥, 2019.07-2020.02, NAIST, Completed).

#2 Tianlong Zhang, Femtosecond laser in combination with microfluidic device for high-throughput and high-purity separation of exosomes (PI, 46000 ¥, 2020.04-2021.02, Japan Science Society, Completed).

#3 Tianlong Zhang, NAIST-MQ double degree Project 2020-2023 (Main Role, Completed).

#4 Tianlong Zhang, Xiaoming Feng, et al, Development of a microfluidic platform for the separation of marine microbial cells (PI, 250000 ¥, 2023-2026, JUST 1022932303, On-going).

Publications

Co-author Journal Publications First Author Conference Publications First/Corresponding Author Journal Publications

#1 Machine learning-based impedance system for real-time recognition of antibiotic-susceptible bacteria with parallel cytometry. Tao, Tang, Xun Liu, Yapeng Yuan, Ryota Kiya, Tianlong Zhang, Yang Yang, Shiro Suetsugu, Yoichi Yamazaki, Nobutoshi Ota, Koki Yamamoto, Hironari Kamikubo, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, YaxiaerYalikun. Sensors and Actuators B: Chemical. (2022) 132698.

#2 Assessment of the electrical penetration of cell membranes using four-frequency impedance cytometry.Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Yang Yang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa and Yaxiaer Yalikun. Microsystems & nanoengineering, (2022) 8, 1-12.

#3 Parallel impedance cytometry for real-time screening of bacterial single cells from nano- to microscale. Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Yang Yang, Yoichi Yamazaki, Hironari Kamikubo, Yo Tanaka, Ming Li, Yoichiroh Hosokawa and Yaxiaer Yalikun. ACS sensors. (2022).

#4I mpedance-based tracking of the loss of intracellular components in microalgae cells. Tao Tang, Xun Liu, Yapeng Yuan, Tianlong Zhang, Ryota Kiya, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa and Yaxiaer Yalikun. Sensors and Actuators B: Chemical. (2022) 358, 131514.

#5 Dual-frequency impedance assays for intracellular components in microalgal cells. Tao Tang, Xun Liu, Yapeng Yuan, Ryota Kiya, Yigang Shen, Tianlong Zhang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa andYaxiaer Yalikun. Lab on a Chip. (2022) 22, 550-559.

#6 Microscopic impedance cytometry for quantifying single cell shape. Tao Tang, Xun Liu, Ryota Kiya, Yigang Shen, Yapeng Yuan, Tianlong Zhang, Kengo Suzuki, Yo Tanaka, Ming Li, Yoichiroh Hosokawa and Yaxiaer Yalikun. Biosensors and Bioelectronics. (2021)193, 113521.

#7 Hemodynamic shear flow regulates biophysical characteristics and functions of circulating breast tumor cells reminiscent of brain metastasis.Jin, Jing, Kai Tang, Ying Xin, Tianlong Zhang, and Youhua Tan. Soft Matter 14, no. 47 (2018): 9528-9533.

#8 Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats. Fang, Juan, Jiazi Gao, He Gong, Tianlong Zhang, Rui Zhang, and Bangchao Zhan. BioMedical Engineering OnLine 18, no. 1 (2019): 1-18.

#9 Micro/Nano Hierarchical Dumbbell-like and Micropapillae Structure Improves Light Absorption and Facilitates Anti-icing/Deicing Performance. Zhizhong Wang, Xiaoming Feng, Yaxiaer Yalikun, Fengqin Li, Yan Li, Lei Zhao, Tianlong Zhang, Guizhong Tian. Langmuir (2024).

#1 Tianlong Zhang, et al. Femtosecond laser-processed pattern on glass substrate for focusing microparticles in fluid. The 80th JSAP autumn meeting 2019, Hokkaido, Japan

#2 Tianlong Zhang, et al. Femtosecond Laser-etched Glass Pattern for Aligning Particles in Microfluidic Channel. The 92th JLPS meeting 2019, Japan

#3 Tianlong Zhang, et al. Laser Engraved Microstructure for Arranging Particle Flowing in a Glass Microfluidic Channel. The 81th JSAP autumn meeting 2020, Hokkaido, Japan

#4 Tianlong Zhang, et al. FOCUSING OF MICROPARTICLES AT LOW REYNOLDS NUMBERS. MicroTAS 2020, Hawaii, USA (peer reviewed international conference)

#5 Tianlong Zhang, et al. Microstructure to align live cells in microfluidic channels under low-Reynolds-number flow condition. TOIN 15th International Symposium on Biomedical Engineering. 2020. Toin University of Yokohama, Kanagawa, Japan

#6 Tianlong Zhang, et al. Femtosecond laser engraved grooves in a microfluidic channel for micro-particle separation. The 22nd International Symposium on Laser Precision Microfabrication. 2021. Virtual On-Demand Conference. Japan

#7 Tianlong Zhang, et al. MICROFLUIDIC PARTICLE SEPARATION USING GLASS STRUCTURES. MicroTAS 2021 (peer reviewed international conference)

#8 Tianlong Zhang, et al. LASER ENGRAVED GROOVES FOR MICROPARTICLE FOCUSING. MicroTAS 2021 (peer reviewed international conference)

#9 Tianlong Zhang, et al. VISCOELASTIC SEPARATION OF DRUG-TREATED E. COLI BY SHAPE. MicroTAS 2022 (peer reviewed international conference)

#10 Tianlong Zhang, et al. SIZE-BASED SEPARATION OF E. COLI USING VISCOELASTIC MICROFLUIDICS. MicroTAS 2023. (peer reviewed international conference)

#11 Tianlong Zhang, et al. SHEATH-AIDED INERTIAL SEPARATION OF BLOOD CELLS BY SIZE. (peer reviewedinternational conference)

#12 Tianlong Zhang, et al. CO-FLOW OF NEWTONIAN AND VISCOELASTIC FLUIDS FOR BACTERIA SEPARATION BY SIZE IN A MICROCHANNEL. MicroTAS 2023. (peer reviewed international conference)

#13 Tianlong Zhang, et al. SEPARATION OF TWO BACTERIAL SPECIES USING VISCOELASTIC FLOWS. MicroTAS 2023. (peer reviewed international conference)

#1 Tianlong Zhang, Jiazi Gao, Juan Fang, and He Gong. Multiscale investigation on the effects of additional weight bearing in combination with low-magnitude high-frequency vibration on bone quality of growing female rats. Journal of Bone and Mineral Metabolism 36 (2018): 157-169. (IF=2.3)

#2 Tianlong Zhang, Zhen-Yi Hong, Shi-Yang Tang, Weihua Li, David W. Inglis, Yoichiroh Hosokawa, Yaxiaer Yalikun, and Ming Li. Focusing of sub-micrometer particles in microfluidic devices. Lab on a Chip 20, 1 (2020): 35-53. (IF=7.4)

#3 Tianlong Zhang, Hangrui Liu, Kazunori Okano, Tao Tang, Kazuki Inoue, Yoichi Yamazaki, Hironari Kamikubo et al. Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics. Lab on a Chip 22, 15 (2022): 2801-2809. (IF=6.4)

#4 Tianlong Zhang, Yigang Shen, Ryota Kiya, Dian Anggraini, Tao Tang, Hanaka Uno, Kazunori Okano et al. Focusing of particles in a microchannel with laser engraved groove arrays. Biosensors 11, 8 (2021): 263. (IF=5.9)

#5 Tianlong Zhang, Misuzu Namoto, Kazunori Okano, Eri Akita, Norihiro Teranishi, Tao Tang, Dian Anggraini et al. Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers. Scientific Reports 11, 1 (2021): 1652.(IF=5.0)

#6 Tianlong Zhang, Amy K. Cain, Lucie Semenec, Ling Liu, Yoichiroh Hosokawa, David W. Inglis, Yaxiaer Yalikun, and Ming Li. Microfluidic separation and enrichment of Escherichia coli by size using viscoelastic flows. Analytical Chemistry 95, 4 (2023): 2561-2569. (IF=8.0)

#7 Tianlong Zhang, Amy K. Cain, Lucie Semenec, Joanna Valanie Pereira, Yoichiroh Hosokawa, Yaxiaer Yalikun, and Ming Li. Bacteria separation and enrichment using viscoelastic flows in a straight microchannel. Sensors and Actuators B: Chemical 390 (2023): 133918. (IF=9.2)

#8 Tianlong Zhang, David W. Inglis, Long Ngo, Yuling Wang, Yoichiroh Hosokawa, Yaxiaer Yalikun, and Ming Li. Inertial separation of particles assisted by symmetrical sheath flows in a straight microchannel. Analytical Chemistry 95, 29 (2023): 11132-11140. (IF=8.0)

#9 Tianlong Zhang, Dino Di Carlo, Chwee Teck Lim, Tianyuan Zhou, Guizhong Tian, Tao Tang, Amy Q. Shen et al. Passive microfluidic devices for cell separation. Biotechnology Advances (2024): 108317. (IF=16.0)

#10 Dian Anggraini, Tianlong Zhang (Co-first Author), Xun Liu, Kazunori Okano, Yo Tanaka, Naoyuki Inagaki, Ming Li, Yoichiroh Hosokawa, Sohei Yamada, Yaxiaer Yalikun. Guided axon outgrowth of neurons by molecular gradients generated from femtosecond laser-fabricated micro-holes. Talanta, 267 (2024): 125200. (IF=6.1)

#11 Liu, Xun, Tianlong Zhang (Corresponding Author), Tao Tang, Yapeng Yuan, Doudou Ma, Yang Yang, Guizhong Tian, Yoichiroh Hosokawa, and Yaxiaer Yalikun (Corresponding Author). The Parameter Investigation of Electrical Impedance Cytometry for Droplet Measurement. IEEE Sensors Journal (2024). (IF=4.3)

Patents

Team

Awards

Honours

#1 Tianlong Zhang, Jilin University Outstanding Graduate Scholarship, 2014-2015.

#2 Tianlong Zhang, International Cotutelle Macquarie University Research Excellence Scholarship (iMQRES), 2021-2023.

#3 Tianlong Zhang, Excellence award in oral presentation at TOIN 15th International Symposium on Biomedical Engineering. 2020. Toin University of Yokohama, Kanagawa, Japan

#4 Tianlong Zhang, et al. High-quality paper in Biosensors 2022.

#5 Tianlong Zhang, Whiterock Serendipity Award in 2022.

This award is annually given to two young researchers or two groups of young researchers who have made serendipitous discoveries or have developed serendipity-enabling technologies.

Essay