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Wangdongxu
Associate professor
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  • Introduction

    Dongxu Wang, male, PhD, Associate Professor, Master's supervisor, mainly engaged in research on food nutrition and toxicology, food nutrition and health, and the development of functional foods.

    Personal e-mail: wdx@just.edu.cn; justwdx@163.com.

    In more than 70 academic papers have been published in important domestic and international journals in this field, such as Journal  of Agricultural and Food Chemistry, Journal of Pineal Research, Redox  Biology, Food Chemistry, Current Opinion in Food Science, Food Research  International, Journal of Functional Foods, Food & Function, Food and  Chemical Toxicology, Frontiers in Nutrition (with a total IF 260.2), including more than 40 first and corresponding authors, 5 authorized invention patents, and one chapter of John Wiley & Sons publishing house's Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology.

    Currently, is a member of the Youth Work Committee of the China Tea Society and is a guest editor of Molecules [IF 4.927]; As a Reviewer in more than 20 journals in the field of food science and biomedicine, including Food Chemistry, Food Research International, Molecular Nutrition and Food Research, Environmental Science & Technology, Food and Chemical Toxicology, Journal of Functional Foods, Food & Function, International Immunopharmacology, Frontiers in Nutrition, Nutrients, Foods, Journal of Food Biochemistry, etc.  

    Representative scientific research projects:

    1. The Youth Talent Support Project of the China Association for Science and Technology, YESS201700162017/01-2019/12, 450,000 RMB, hosted

    2. Jiangsu Provincial Natural Science Foundation Youth Project, BK20210881, 2021/07-2024/06, 200,000 RMB, hosted  

    3. Anhui Provincial Natural Science Foundation Youth Project, 1708085QC79, 2017/07-2019/07, 80,000 RMB, hosted

    4. National Natural Science Foundation of China - General Project, 31972459,2020/01-2023/12, 580,000 RMB, participated 3/9

    5. National Natural Science Foundation of China - Youth Project, 31601424,2017/01-2019/12, 200,000 RMB, participated 3/7

    6. Anhui Province Key Research and Development Plan, 1804b06020367,2018/03-2021/02, 600,000 RMB, participated 4/8

    7. Anhui Province Key Research and Development Plan, 1904b11020038,2019/01-2021/12, 600,000 RMB, participated 4/9

    8. Anhui Provincial Natural Science Foundation General Project, 1408085MKL39, 2015/01-2016/12, 80,000 RMB, participated 3/6  

    Representative Awards:

    1. China Federation of Commerce Science and Technology Award (Third Prize, Ranking 5/8) (2022)  

    2. Anhui Provincial Science and Technology Award Natural Science Award (Third Prize, Ranking 4/5) (2019)  

    3. Youth Science and Technology Award of China Tea Society (Ranking 1/1) (2017)  

    Representative scientific research papers and works (# is the impact factor of publication year, * is the corresponding author):

    36) Taotao Wang, Hong Xu, Yu Guo, Yuanxin Guo, Huanan Guan*, Dongxu Wang*, Perfluorodecanoic acid promotes high-fat diet-triggered adiposity and hepatic lipid accumulation by modulating the NLRP3/caspase-1 pathway in male C57BL/6J mice. Food and Chemical Toxicology. 2023,178:113943. (SCI, JCR Q1, IF 4.3#)

    35) Taotao Wang, Hong Xu, Shanshan Wu, Yuanxin Guo*, Guangshan Zhao*, Dongxu Wang*, Mechanisms underlying the effects of the green tea polyphenol EGCG in sarcopenia prevention and management. Journal of Agricultural and Food Chemistry. 2023,  71(25):9609-9627. (SCI, JCR Q1, IF 6.1#)

    34) Ruixia  Dong, Junjie Pan, Guangshan Zhao*, Shiqiong Wang, Ning Li, Lianjun  Song, Xianqing Huang, Shuxing Miao, Junhui Ying, Fangying Wu, Dongxu Wang*, et al., Antioxidant, antihyperglycemic, and antihyperlipidemic properties of Chimonanthus salicifolius S. Y. Hu leaves  in experimental animals: modulation of thioredoxin and glutathione  systems, renal water reabsorption, and gut microbiota. Frontiers in Nutrition. 2023, 10:1168049. (SCI, JCR Q1, IF 5.0#)

    33) Taotao Wang, Hong Xu, Ruixia Dong, Shanshan Wu, Yuanxin Guo*, Dongxu Wang*, Effectiveness  of targeting the NLRP3 inflammasome by using natural polyphenols: A  systematic review of implications on health effects. Food Research International. 2023, 165:112567. (SCI, JCR Q1, IF 8.1#)

    32) Taotao Wang, Hong Xu, Yu Guo, Zhanming Li, Hua Ye, Liang Wu, Yuanxin Guo*, Dongxu Wang*, Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells. Food and Chemical Toxicology. 2023, 171:113520. (SCI, JCR Q1, IF 4.3#)

    31) Qiuyan Ban, Wenjing Chi, Yu Tan, Shiqiong Wang, Ning Li, Lianjun Song, Xianqing Huang*, Dongxu Wang*, et al.,  Melatonin improved glucose homeostasis is associated with the  reprogrammed gut microbiota and reduced fecal levels of short-chain  fatty acids in db/db mice. Food Science & Nutrition. 2023, 1:11-15. (SCI, JCR Q2, IF 3.9#)

    30) Yanyan Zhang, Yue Xi, Changshui Yang, Weijuan Gong, Chengyin Wang, Liang Wu*, Dongxu Wang*, Short-chain  fatty acids attenuate 5-fluorouracil-induced THP-1 cell inflammation  through inhibiting NF-κB/NLRP3 signaling via glycerolphospholipid and  sphingolipid metabolism. Molecules. 2023, 28(2), 494. (SCI, JCR Q2, IF 4.6#)

    29) Yijun  Wang, Tiantian Liu, Yanmei Xie, Na Li, Yan Liu, Jiaqiang Wen, Man  Zhang, Wanjie Feng, Jinbao Huang, Yuanxin Guo, Tufy Kabbas Junior, Dongxu Wang*, et al., Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice. Food Research International. 2022, 162:112008. (SCI, JCR Q1, IF 8.1#)

    28) Dongxu Wang, et al., Recent advances in the effects of dietary polyphenols on inflammation in vivo:  potential molecular mechanisms, receptor targets, safety issues, and  uses of nano-delivery system and polyphenol polymers. Current Opinion in Food Science. 2022, 48:100921. (SCI, JCR Q1, IF 9.9#)

    27) Dongxu Wang, et al., Green  tea polyphenols upregulate the Nrf2 signaling pathway and suppress  oxidative stress and inflammation markers in D-galactose-induced liver  aging in mice. Frontiers in Nutrition. 2022, 9:836112. (SCI, JCR Q1, IF 5.0#)

    26) Man Yan, Xiang Li, Chang Sun, Jiajun Tan, Yuanyuan Liu, Mengqi Li, Zishang Qi, Jiayuan He, Dongxu Wang*, et al.,  Sodium butyrate attenuates AGEs-induced oxidative stress and  inflammation by inhibiting autophagy and affecting cellular metabolism  in THP-1 cells. Molecules. 2022, 27(24), 8715.(SCI, JCR Q2, IF 4.6#)

    25) Chengxue Yi, Wen Sun, Longkun Ding, Man Yan, Chang Sun, Chen-guang Qiu, Dongxu Wang*, et al.,  Short-chain fatty acids weaken ox-LDL-induced cell inflammatory injury  by inhibiting NLRP3/caspase-1 pathway and affecting cellular metabolism  in THP-1 cells. Molecules. 2022, 27(24), 8801.(SCI, JCR Q2, IF 4.6#)

    24) ZhanmingLi, Zhongyang Ren, Lin Zhao, Lin Chen, Yue Yu, Dongxu Wang, et al.,  Unique roles in health promotion of dietary flavonoids through gut  microbiota regulation: Current understanding and future perspectives. Food Chemistry. 2022, 399:133959. (SCI, JCR Q1 IF 8.8#)

    23) Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, et al.,L-Theanine inhibits (-)-epigallocatechin-3-gallate oxidation via chelating copper. Journal of Agricultural and Food Chemistry. 2022, 70(25):7751-7761. (SCI, JCR Q1, IF 6.1#)

    22) Xiaohong Feng, Longkun Ding, Guifang Ma, Ying Zhang, Yefu Sun, Zhengzhang Li, Xiaojun Tao, Asmaa Ali, Dongxu Wang*, et al., Lactobacillus rhamnosus TR08  improves dyslipidemia in mice fed with a high fat diet via regulating  the intestinal microbiota, reducing systemic inflammatory response and  promoting sphingomholipid metabolism. Molecules. 2022, 27(21), 7357.(SCI, JCR Q2, IF 4.6#)

    21) Wenjing Liao, Suyu Liu, Yunxi Chen, Yashuai Kong, Dongxu Wang, et al., Effects of Keemun and Dianhong black tea in alleviating excess lipid accumulation in the liver of obese mice: A comparative study. Frontiers in Nutrition. 2022, 9:849582. (SCI, JCR Q1, IF 5.0#)

    20) Nora Pap, Marina Fidelis, Luciana Azevedo, Mariana Araújo Vieirado Carmo, Dongxu Wang, et al., Berry  polyphenols and human health: evidence of antioxidant,  anti-inflammatory, microbiota modulation, and cell-protecting effects. Current Opinion in Food Science. 2021, 42:167-186. (SCI, JCR Q1, IF 9.8#)

    19) Dongxu Wang, et al., Green  tea polyphenols mitigate plant lectins-induced liver inflammation and  immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling  pathways, Food and Chemical Toxicology. 2020, 144:111576.(SCI, JCR Q1, IF 6.025#)

    18) Dongxu Wang,  et al., Ameliorative effects of L-theanine on dextran sulfate sodium  induced colitis in C57BL/6J mice are associated with the inhibition of  inflammatory responses and attenuation of intestinal barrier disruption,  Food Research International. 2020, 137:109409. (SCI, JCR Q1, IF 6.475#)

    17) Dongxu Wang,  et al., Green tea polyphenols and epigallocatechin-3-gallate protect  against perfluorodecanoic acid induced liver damage and inflammation in  mice by inhibiting NLRP3 inflammasome activation, Food Research International. 2020, 127:108628. (SCI, JCR Q1, IF 6.475#)

    16) Jinbao Huang, Wenjiao Li, Wenjing Liao, Qing Hao, Dongxu Wang, et al.,  Green tea polyphenol (-)-epigallocatechin-3-gallate alleviates  non-alcoholic fatty liver disease and ameliorates intestinal immunity in  mice fed a high fat diet, Food & Function. 2020, 11(11):9924-9935. (SCI, JCR Q1, IF 5.396#)

    15) Dongxu Wang,  et al., Green tea polyphenols prevent lipopolysaccharide-induced  inflammatory liver injury in mice by inhibiting NLRP3 inflammasome  activation, Food & Function. 2019, 10:3898-3908. (SCI, JCR Q1, IF 4.171#)

    14) Dongxu Wang, et al., Anticancer activity and mechanism of total saponins from the residual seed cake of Camellia oleifera Abel. in hepatoma-22 tumor-bearing mice, Food & Function. 2019, 10:2480-2490. (SCI, JCR Q1, IF 4.171#)

    13) Dongxu Wang,  et al., Protective effect and mechanism of theanine on  lipopolysaccharide-induced inflammation and acute liver injury in mice, Journal of Agricultural and Food Chemistry. 2018, 66:7674-7683. (SCI, JCR Q1, IF 3.571#)

    12) Dongxu Wang,  et al., Theanine supplementation prevents liver injury and heat shock  response by normalizing hypothalamic-pituitary-adrenal axis  hyperactivity in mice subjected to whole body heat stress, Journal of Functional Foods. 2018, 45:181-189. (SCI, JCR Q1, IF 3.197#)

    11) Yijun Wang, Zhipeng Kan, Dongxu Wang, et al., Differences in chemical composition among commercially important cultivars of Genus Camellia. Journal of Agricultural and Food Chemistry. 2018, 67:5457-5464. (SCI, JCR Q1, IF 3.571#)

    10) Dongxu Wang,  et al., Green tea infusion protects against alcoholic liver injury by  attenuating inflammation and regulating PI3K/Akt/eNOS pathway in C57BL/6  mice, Food & Function. 2017, 8:3165-3177. (SCI, JCR Q1, IF 3.289#)

    9) Ruixia Dong, Dongxu Wang, et al.,  Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic  thioredoxin and glutathione systems in selenium-optimal mice but  activates hepatic Nrf2 responses in selenium-deficient mice, Redox Biology. 2016, 10:221-232. (SCI,JCR Q1, IF 6.337#)

    8) Jianfa Zong, Dongxu Wang, et al., Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro, RSC Advances. 2016, 6, 91386. (SCI,JCR Q2, IF 3.108#)

    7) Yaqing Wei, Pingping Chen, Tiejun Ling, Yijun Wang, Ruixia Dong, Chen Zhang, Longjie Zhang, Manman Han, Dongxu Wang, et al., Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG, Food Chemistry. 2016, 204:218-226. (SCI, JCR Q1, IF 4.529#)

    6) Manman Han, Guangshan Zhao, Yijun Wang, Dongxu Wang, et al., Safety and anti-hyperglycemic efficacy of various tea types in mice, Scientific Reports. 2016, 6:31703. (SCI, JCR Q2, IF 4.259#)

    5) Dongxu Wang, et al., Melatonin attenuates (-)-epigallocatehin-3-gallate-triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice, Journal of Pineal Research. 2015, 59(4):497-507. (SCI, JCR Q1, IF 9.314#)

    4) Dongxu Wang,  et al., Green tea polyphenol (-)-epigallocatechin-3-gallate triggered  hepatotoxicity in mice: Responses of major antioxidant enzymes and the  Nrf2 rescue pathway, Toxicology and Appllied Pharmacology. 2015, 283(1):65-74. (SCI, JCR Q1, IF 3.847#)

    3) Le Zhang, Shanshan Wu, Dongxu Wang, et al., Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG, Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology, Chapter 8, 2014, John Wiley & Sons, Inc. 

    2) Shanshan Wu, Kang Sun, Xin Wang, Dongxu Wang, et al.,  Protonation of epigallocatechin-3-gallate (EGCG) results in massive  aggregation and reduced oral bioavailability of EGCG-dispersed selenium  nanoparticles, Journal of Agricultural and Food Chemistry. 2013, 61(30):7268-7275. (SCI, JCR Q1, IF 3.107#)

    1) Dongxu Wang,et al., Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention, International Journal of Nanomedicine. 2012, 7:1711-1721. (SCI, JCR Q1,IF 4.976#)

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