生物技术学院 蚕业研究所
通讯地址：江苏省镇江市丹徒区长晖路666号17#楼223室
个人邮箱：zyssri@just.edu.cn
邮政编码：212100
办公地点：长山校区生物学院楼223室
传真：
工学博士、教授、硕士生导师、国家蚕桑产业技术体系岗位科学家, 中国蚕学会养蚕专业委员会副主委，中国生物材料学会烧创伤创面修复材料分会常务委员。主要从事蚕丝蛋白组织工程材料、创面修复及养蚕技术研究。主持国家蚕桑产业技术体系项目、江苏省自然基金、镇江市重点研发项目等多项，参与国家自然科学基金、国际合作项目、教育部科研项目等十余项；发表SCI论文30余篇，授权发明专利10余项。在国际上首次合成了真正意义上的三维纯丝胶蛋白水凝胶并开发出了多种具有不同特性且性能优良的丝胶蛋白水凝胶、蚕丝蛋白生物活性支架及创面敷料；创新提取工艺制备了系列具有高活性的丝胶蛋白；开发出的新材料已被多家单位采购或采用,在生物医药领域具有广阔的用途和巨大的潜在经济价值。
蚕丝生物医用材料与创面修复
#为共一，*为通信作者
Paper:
[1] Zilong Gao, Xiang Li, Yiqing Jiang, Beihui Lu, Guozheng Zhang, Wengong Huang , Yurong Li, Yeshun Zhang*. Bioactive hydrogel dressing with inherent antimicrobial and antioxidant activity for wound healing, Biomacromolecules, 2025, 26 (9), 6091–6103.
[2]Limin Bai, Chuheng Guo, Siwei Cao, Xiaowei Zhang, Xiaomei Li, Qiangwei Fang, Yeshun Zhang*, Gang Xu*.A novel injectable Sericin/Nano-hydroxyapatite hydrogel as a dermal filler for soft tissue augmentation.International Journal of Biological Macromolecules, 2025, 320,145814.
[3] Yurong Li#, Yongkang Wei#, Zilong Gao, Guozheng Zhang, Mingkun Zhu, Hui Yan,Yeshun Zhang*. A multifunctional sericin hydrogel system fabricated via one-step acetic acid induction for wound management
[4] Xiang Li, Yurong Li, Akou May Tehoungue, Qianyan Wang, Hui Yan, Guozheng Zhang, Yeshun Zhang*. An antibacterial hydrogel based on silk sericin cross-linking glycyrrhizic acid and silver for infectious wound healing, Biomacromolecules, 2025,26 (4), 2356–2367.
[5] Xingyue Wang#, Susu Wang#, Akoumay Tehoungue , Yurong Li, Xiang Li, Yanhui, Mingkun Zhu, Guozheng Zhang, Yeshun Zhang*. A robust visualized sericin hydrogel dressing with excellent antioxidative and antimicrobial activities facilitates diabetic wound healing. Journal of the Mechanical Behavior of Biomedical Materials, 2025,165, 106927.
[6] Xinyu Cao#, Xinyi Ding#, Rui Chen, Yurong Li, Akoumay Tehoungue, Wengong Huang, Guoping Kang, Guozheng Zhang,Yeshun Zhang*.Explore the antioxidative and tyrosinase inhibitory activity of green sericin resources from different fibroin-deficient silkworm varieties. Journal of Food Measurement and Characterization.2025, 19, 593-602.
[7] Zhanyan Du#, Zhihan Yan#, Yanan Guo#, Ruixi Ye, Akoumay Tehoungue, Yurong Li, Guozheng Zhang, Yeshun Zhang*. A high stretchable, transparent sericin hydrogel with antioxidant activity formed by CaCl2-formic acid dissolution system. Polymer, 2025, 317, 127929.
[8] Yongkang Wei#, Yanwei Li#, Yurong Li, Gang Xu, Tangfeng Wu, Xiang Li, Ruixi Ye, Meilin Xi, Xiaomei Li, Guozheng Zhang, Yeshun Zhang*. Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing. Biomed. Mater. 2024, 19, 035008.
[9] Yeshun Zhang#*, Xinyu Cao#, Jingya Zhang, Guozheng Zhang, Mingkun Zhu, Hui Yan, Yurong Li*. A novel injectable sericin hydrogel with strong fluorescence for tracing. International Journal of Biological Macromolecules, 2023, 258,12900.
[10] Limin Bai, Xiaowei Zhang, Xiaomei Li, Susu Wang, Yeshun Zhang*, Gang Xu*. Impact of a novel hydrogel with injectable platelet-rich fibrin in diabetic wound healing.Journal of Diabetes Research, 2023, 7532637.
[11] Yurong Li#, Yongkang Wei#, Guozheng Zhang, Yeshun Zhang*. Sericin from fibroin-deficient silkworms served as a promising resource for biomedicine, Polymers, 2023,15, 2941.
[12] Ruixi Ye#, Siyu Liu#, Wenkai Zhu#, Yurong Li, Long Huang, Guozheng Zhang, Yeshun Zhang*. Synthesis, characterization, properties, and biomedical application of chitosan-based hydrogels. Polymers 2023, 15, 2482.
[13] Yanwei Li#, Susu Wang#, Yurong Li#, Guozheng Zhang, Tangfeng Wu, Yongkang Wei, Xinyu Cao, Hui Yan, Peisheng Liang, Zihan Yan, Yanan Guo, Yeshun Zhang*. Resveratrol loaded native silk fiber-sericin hydrogel double interpenetrating bioactive wound dressing facilitates full-thickness skin wound healing.Biomed. Mater. 2023, 18, 045007
[14] Yanwei Li#, Tangfeng Wu#, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang*. A native sericin wound dressing spun directly from silkworms enhances，Colloids and Surfaces B: Biointerfaces 2023,225, 113228.
[15] Yeshun Zhang#*, Susu Wang#, Yurong Li, Xiang Li, Zhanyan Du, Siyu Liu, Yushuo Song, Yanyan Li, Guozheng Zhang. A sterile, injectable, and robust sericin hydrogel prepared by degraded sericin. Gels, 2013,9,948.
[16] M. Zhu, M. Yan, J. Chen, H. Li, Y. Zhang* MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H2O2-induced oxidative stress, Poult Sci 102(10) (2023) 103006.
[17] Ziniu Zhao, Yihan Liu, Shuo Yang, Yurong Li, Yeshun Zhang, Hui Yan* Fast detection of the tenderness of mulberry leaves by a portable near-infrared spectrometer with variable selection，Infrared Physics & Technology, 2023, 113,104818.
[18] Yeshun Zhang*, Wu Tangfeng, Congyi Shen, Gang Xu, Heguang Chen, Hui Yan, Meng Xiong, Guozheng Zhang*. A robust sericin hydrogel formed by a native sericin from silkworm bodies, Fibers and polymers, 2022
[19] Yeshun Zhang#, Heguang Chen#, Yulin Li, Ai Fang, Tangfeng Wu, Congyi Shen, Yuying Zhao, Guozheng Zhang*, A transparent sericin-polyacrylamide interpenetrating network hydrogel as visualized dressing material, Polymer testing, 2020,87, 106517
[20] Yeshun Zhang#，Rulan Jiang#, Ai Fang, Yuying Zhao, Tangfeng Wu, Xitao Cao, Peisheng Liang, Dingguo Xia, Guozheng Zhang*. A highly transparent, elastic, injectable sericin hydrogel induced by ultrasound, Polymer testing, 2019, 77:105890.
[21] Yeshun Zhang#，Yuying Zhao#, Xiaobai He, Ai Fang, RulanJiang, Tangfeng Wu, Heguang Chen, XitaoCao, Peisheng Liang, DingguoXia, Guozheng Zhang*. A sterile self-assembled sericin hydrogel via a simple two-step process, Polymer testing, 2019, 80:106016.
[22] Yeshun Zhang, Jia Liu, Lei Huang, Zheng Wang, Lin Wang*. Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery. Scientific Reports, doi:10.1038/srep12374, 2015.
[23] Zheng Wang#, Yeshun Zhang#, Jinxiang Zhang, Lei Huang, Jia Liu, Yongkui Li, Guozheng Zhang, Subhas C. Kundu, Lin Wang*. Exploring natural silk protein sericin for regenerative medicine: an injectable, photoluminescent, cell-adhesive 3D hydrogel. Scientific Reports, doi:10.1038/srep07064, 2014.
[24] Wanpeng Liu, Zhitao Zhou, Shaoqing Zhang, Zhifeng Shi, Justin Tabarini, Woonsoo Lee, Yeshun Zhang, S. N. Gilbert Corder, Xinxin Li, Fei Dong, Liang Cheng,Mengkun Liu, David L. Kaplan, Fiorenzo G. Omenetto, Guozheng Zhang,* Ying Mao,*and Tiger H. Tao* Precise protein photolithography (p3): high performance biopatterning using silk fibroin light chain as the resist，Adv. Sci. 2017, 4:1700191.
[25] Zhitao Zhou，Zhifeng Shi，Xiaoqing Cai，Shaoqing Zhang，Stephanie G. Corder， Xinxin Li，Yeshun Zhang，Guozheng Zhang，Liang Chen，Mengkun Liu，David L. Kaplan，Fiorenzo G. Omenetto，Ying Mao，Zhendong Tao，Tiger H.Tao，The use of functionalized silk fibroin films as a platform for optical diffraction-based sensing applications，Advanced materials，2017.2.13.
[26] Changsheng Chen, Fei Zeng, Xiao Xiao, Zhen Wang, Xiaoli Li, Weirong Tan, Weiqiang Liu, Yeshun Zhang, Zhending She, Songjian Li Three-dimensionally printed silk-sericin-based hydrogel scaffold: a promising visualized dressing material for real-time monitoring of wounds. ACS Appl Mater Interfaces. 2018,10 (40):33879-33890.
[27] Keyin Liu, Zhifeng Shi, Shaoqing Zhang, Zhitao Zhou, Long Sun, Tao Xu, Yeshun Zhang, Guozheng Zhang, Xinxin Li, Liang Chen, Ying Mao, Tiger H. Tao. A silk cranial fixation system for neurosurgery, Advanced healthcare materials, 2018,1701359.
[28] X. Xiao, C.S. Chen, W.Q. Liu, Y.S. Zhang, Structure, features and biomedical applications of silk sericin, Prog Chem, 29 (2017) 513-523.
[29] Y. Zhang, D.G. Xia, Q.L. Zhao, G.Z. Zhang, Y.S. Zhang, Z.Y. Qiu, D.X. Shen, C. Lu, Label-free proteomic analysis of silkworm midgut infected by Bombyx mori nuclear polyhedrosis virus, J Proteomics, 200 (2019) 40-50.
[30] Yanwei Li, Liang Yao, Liwei Zhang, Yeshun Zhang, Tao Zheng, Lei Liu, Lei Zhang. Enhanced physicochemical stabilities of cyanidin-3-O-glucoside via combination with silk fibroin peptide, Food Chemistry 355 (2021) 129479
[31] Y.K. Li, Y. Huang, P. Pan, X. Che, Y.R. Zhang, Y.S. Zhang, A. Amal, X. Li, W.J. Niu, N.C. Luo, W. Zhang, D.L. Gao, Q.P. Tan, Q.W. Zhang, X.W. Xing, Z. Luo, J.G. Wu, Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response, Appl Mater Today 25 (2021)
[32]Dingguo Xia，Yadong Wei, Guozheng Zhang，Qiaoling Zhao，Yeshun Zhang, Zhonghuai Xiang，Cheng Lu. cDNA cloning, expression, and enzymatic activity of a novel endogenous cellulase from the beetle Batocera horsfieldi,GENE, 2013,514 (1) :62-68.
Book:
Guozhong Lv, Yingjun Guo, Xue chen, Yeshun Zhang (associate editor).Materials Science for Repairing Skin and Soft Tissue Injuries in China,Zhengzhou University Press, 2024.
乔晓月, 曹喜涛, 季更生, 屠洁, 李强, 张业顺, 张国政. 一种白黎芦醇丝素蛋白包埋物及其制备方法和在黄酒中制备中的应用(201811407162.1)
王琳,王征,张业顺,刘佳,黄雷,乞超,徐鲁明,宋煜,杨文,谢洪建,王健,张诚.一种丝胶蛋白-海藻酸盐复合水凝胶及其制备方法(ZL 201510097717.7)
王琳,张业顺,黄雷,刘佳,王征,李永奎,杨文,乞超.丝胶蛋白水凝胶的制备方法及其应用(ZL 201410071402.0)
陆莹霞,张业顺,张国政,李聪,张议文,方梦莹,曹喜涛,凌敏.史紫凌.蚕丝蛋白创伤敷料及其制备方法和应用(201811249902.3)
杨洁,陆莹霞,江茹兰,张业顺,张国政,张议文,方梦莹,凌敏,史紫凌,李聪.功能性丝胶蛋白水凝胶及其制备方法和应用(201910194404.1)
张国政,张业顺,方瑷,吴堂凤,梁培生,李思儒,何小柏,夏定国,布塔库孜.木拉提别克.一种蚕丝蛋白生物支架及其制备方法和应用（ZL 201710564056.3）
张业顺,张国政,熊晓东,戴争妍,方瑷,吴堂凤,李木旺,梁培生.一种丝胶蛋白水凝胶及其制备方法和应用( ZL201710981720.4)
张业顺,张国政,方瑷,吴堂凤,陆莹霞,李木旺,梁培生,何小柏,李聪,一种丝胶蛋白创伤敷料及其制备方法和应用（ZL 201710564058.2）
张业顺, 张国政, 陈和光, 方瑷 , 吴堂凤 , 梁培生 , 夏定国 , 何小柏，高机械强度丝胶蛋白水凝胶及其制备方法和应用（201911086861.5）
张业顺 ,沈聪昳, 张国政, 吴堂凤, 钱平, 朱大林, 方瑷, 曹喜涛, 冉素晴. 一种丝胶蛋白水凝胶及其制备方法和应用（202011442869.3）
获奖
1. 第九届全国大学生生命科学竞赛二等奖（项目：丝路领航-丝胶蛋白无血清培养基研发及产业化），指导教师，2024年；
2. 第八届全国生命科学大赛一等奖（项目：鸾凤丝胶——丝胶蛋白新材料研发及产业化），指导教师，2023年；
3. 校优秀硕士论文，指导教师，2023；
4. 全国生命科学大赛三等奖，指导教师，2021年；
5. Best Researcher award, 4 th Edition of International Research Awards on Advanced Nanomaterials and Nanotechnology，2023年；
6. 江苏科技大学2019-2020学年教学优秀奖 (2020年)
7. “蚕丝蛋白生物医用材料的开发及应用”获全省高校、科研院所教职工优秀创新成果奖（第一完成人，2020年）
8. 江苏科技大学优秀教师(2020年)
9. 江苏科技大学本科生创新创业训练计划优秀指导教师 (2020年)
10. “蚕丝蛋白及其应用技术”成果入选首届全国农业科技成果转化大会1000 项优秀农业科技成果(2019年)
11. “新型促皮肤损伤修复蚕丝蛋白敷料的研制”获得16届大学生挑战杯竞赛全国三等奖和江苏省决赛一等奖(指导教师, 2...
12.“不同品种丝胶蛋白替代胎牛血清培养细胞的研究”获江苏科技大学优秀毕业论文(指导教师,2019年)
13.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市第12届哲学社会科学三等奖(第一完成人,2018年)
14.“一带一路”和“大运河”文化带建设背景下镇江蚕桑文化保护与发展策略研究”获镇江市社科应用精品工程二等奖(第二完成人,2018年)
15.“镇江大运河文化带开发与利用研究”获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
16.“大运河镇江段文化遗产的保护与发展策略研究获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
17.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市教育专项研究一等奖1项（第一完成人，2017年）
#为共一，*为通信作者
Paper:
[1] Zilong Gao, Xiang Li, Yiqing Jiang, Beihui Lu, Guozheng Zhang, Wengong Huang , Yurong Li, Yeshun Zhang*. Bioactive hydrogel dressing with inherent antimicrobial and antioxidant activity for wound healing, Biomacromolecules, 2025, 26 (9), 6091–6103.
[2]Limin Bai, Chuheng Guo, Siwei Cao, Xiaowei Zhang, Xiaomei Li, Qiangwei Fang, Yeshun Zhang*, Gang Xu*.A novel injectable Sericin/Nano-hydroxyapatite hydrogel as a dermal filler for soft tissue augmentation.International Journal of Biological Macromolecules, 2025, 320,145814.
[3] Yurong Li#, Yongkang Wei#, Zilong Gao, Guozheng Zhang, Mingkun Zhu, Hui Yan,Yeshun Zhang*. A multifunctional sericin hydrogel system fabricated via one-step acetic acid induction for wound management
[4] Xiang Li, Yurong Li, Akou May Tehoungue, Qianyan Wang, Hui Yan, Guozheng Zhang, Yeshun Zhang*. An antibacterial hydrogel based on silk sericin cross-linking glycyrrhizic acid and silver for infectious wound healing, Biomacromolecules, 2025,26 (4), 2356–2367.
[5] Xingyue Wang#, Susu Wang#, Akoumay Tehoungue , Yurong Li, Xiang Li, Yanhui, Mingkun Zhu, Guozheng Zhang, Yeshun Zhang*. A robust visualized sericin hydrogel dressing with excellent antioxidative and antimicrobial activities facilitates diabetic wound healing. Journal of the Mechanical Behavior of Biomedical Materials, 2025,165, 106927.
[6] Xinyu Cao#, Xinyi Ding#, Rui Chen, Yurong Li, Akoumay Tehoungue, Wengong Huang, Guoping Kang, Guozheng Zhang,Yeshun Zhang*.Explore the antioxidative and tyrosinase inhibitory activity of green sericin resources from different fibroin-deficient silkworm varieties. Journal of Food Measurement and Characterization.2025, 19, 593-602.
[7] Zhanyan Du#, Zhihan Yan#, Yanan Guo#, Ruixi Ye, Akoumay Tehoungue, Yurong Li, Guozheng Zhang, Yeshun Zhang*. A high stretchable, transparent sericin hydrogel with antioxidant activity formed by CaCl2-formic acid dissolution system. Polymer, 2025, 317, 127929.
[8] Yongkang Wei#, Yanwei Li#, Yurong Li, Gang Xu, Tangfeng Wu, Xiang Li, Ruixi Ye, Meilin Xi, Xiaomei Li, Guozheng Zhang, Yeshun Zhang*. Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing. Biomed. Mater. 2024, 19, 035008.
[9] Yeshun Zhang#*, Xinyu Cao#, Jingya Zhang, Guozheng Zhang, Mingkun Zhu, Hui Yan, Yurong Li*. A novel injectable sericin hydrogel with strong fluorescence for tracing. International Journal of Biological Macromolecules, 2023, 258,12900.
[10] Limin Bai, Xiaowei Zhang, Xiaomei Li, Susu Wang, Yeshun Zhang*, Gang Xu*. Impact of a novel hydrogel with injectable platelet-rich fibrin in diabetic wound healing.Journal of Diabetes Research, 2023, 7532637.
[11] Yurong Li#, Yongkang Wei#, Guozheng Zhang, Yeshun Zhang*. Sericin from fibroin-deficient silkworms served as a promising resource for biomedicine, Polymers, 2023,15, 2941.
[12] Ruixi Ye#, Siyu Liu#, Wenkai Zhu#, Yurong Li, Long Huang, Guozheng Zhang, Yeshun Zhang*. Synthesis, characterization, properties, and biomedical application of chitosan-based hydrogels. Polymers 2023, 15, 2482.
[13] Yanwei Li#, Susu Wang#, Yurong Li#, Guozheng Zhang, Tangfeng Wu, Yongkang Wei, Xinyu Cao, Hui Yan, Peisheng Liang, Zihan Yan, Yanan Guo, Yeshun Zhang*. Resveratrol loaded native silk fiber-sericin hydrogel double interpenetrating bioactive wound dressing facilitates full-thickness skin wound healing.Biomed. Mater. 2023, 18, 045007
[14] Yanwei Li#, Tangfeng Wu#, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang*. A native sericin wound dressing spun directly from silkworms enhances，Colloids and Surfaces B: Biointerfaces 2023,225, 113228.
[15] Yeshun Zhang#*, Susu Wang#, Yurong Li, Xiang Li, Zhanyan Du, Siyu Liu, Yushuo Song, Yanyan Li, Guozheng Zhang. A sterile, injectable, and robust sericin hydrogel prepared by degraded sericin. Gels, 2013,9,948.
[16] M. Zhu, M. Yan, J. Chen, H. Li, Y. Zhang* MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H2O2-induced oxidative stress, Poult Sci 102(10) (2023) 103006.
[17] Ziniu Zhao, Yihan Liu, Shuo Yang, Yurong Li, Yeshun Zhang, Hui Yan* Fast detection of the tenderness of mulberry leaves by a portable near-infrared spectrometer with variable selection，Infrared Physics & Technology, 2023, 113,104818.
[18] Yeshun Zhang*, Wu Tangfeng, Congyi Shen, Gang Xu, Heguang Chen, Hui Yan, Meng Xiong, Guozheng Zhang*. A robust sericin hydrogel formed by a native sericin from silkworm bodies, Fibers and polymers, 2022
[19] Yeshun Zhang#, Heguang Chen#, Yulin Li, Ai Fang, Tangfeng Wu, Congyi Shen, Yuying Zhao, Guozheng Zhang*, A transparent sericin-polyacrylamide interpenetrating network hydrogel as visualized dressing material, Polymer testing, 2020,87, 106517
[20] Yeshun Zhang#，Rulan Jiang#, Ai Fang, Yuying Zhao, Tangfeng Wu, Xitao Cao, Peisheng Liang, Dingguo Xia, Guozheng Zhang*. A highly transparent, elastic, injectable sericin hydrogel induced by ultrasound, Polymer testing, 2019, 77:105890.
[21] Yeshun Zhang#，Yuying Zhao#, Xiaobai He, Ai Fang, RulanJiang, Tangfeng Wu, Heguang Chen, XitaoCao, Peisheng Liang, DingguoXia, Guozheng Zhang*. A sterile self-assembled sericin hydrogel via a simple two-step process, Polymer testing, 2019, 80:106016.
[22] Yeshun Zhang, Jia Liu, Lei Huang, Zheng Wang, Lin Wang*. Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery. Scientific Reports, doi:10.1038/srep12374, 2015.
[23] Zheng Wang#, Yeshun Zhang#, Jinxiang Zhang, Lei Huang, Jia Liu, Yongkui Li, Guozheng Zhang, Subhas C. Kundu, Lin Wang*. Exploring natural silk protein sericin for regenerative medicine: an injectable, photoluminescent, cell-adhesive 3D hydrogel. Scientific Reports, doi:10.1038/srep07064, 2014.
[24] Wanpeng Liu, Zhitao Zhou, Shaoqing Zhang, Zhifeng Shi, Justin Tabarini, Woonsoo Lee, Yeshun Zhang, S. N. Gilbert Corder, Xinxin Li, Fei Dong, Liang Cheng,Mengkun Liu, David L. Kaplan, Fiorenzo G. Omenetto, Guozheng Zhang,* Ying Mao,*and Tiger H. Tao* Precise protein photolithography (p3): high performance biopatterning using silk fibroin light chain as the resist，Adv. Sci. 2017, 4:1700191.
[25] Zhitao Zhou，Zhifeng Shi，Xiaoqing Cai，Shaoqing Zhang，Stephanie G. Corder， Xinxin Li，Yeshun Zhang，Guozheng Zhang，Liang Chen，Mengkun Liu，David L. Kaplan，Fiorenzo G. Omenetto，Ying Mao，Zhendong Tao，Tiger H.Tao，The use of functionalized silk fibroin films as a platform for optical diffraction-based sensing applications，Advanced materials，2017.2.13.
[26] Changsheng Chen, Fei Zeng, Xiao Xiao, Zhen Wang, Xiaoli Li, Weirong Tan, Weiqiang Liu, Yeshun Zhang, Zhending She, Songjian Li Three-dimensionally printed silk-sericin-based hydrogel scaffold: a promising visualized dressing material for real-time monitoring of wounds. ACS Appl Mater Interfaces. 2018,10 (40):33879-33890.
[27] Keyin Liu, Zhifeng Shi, Shaoqing Zhang, Zhitao Zhou, Long Sun, Tao Xu, Yeshun Zhang, Guozheng Zhang, Xinxin Li, Liang Chen, Ying Mao, Tiger H. Tao. A silk cranial fixation system for neurosurgery, Advanced healthcare materials, 2018,1701359.
[28] X. Xiao, C.S. Chen, W.Q. Liu, Y.S. Zhang, Structure, features and biomedical applications of silk sericin, Prog Chem, 29 (2017) 513-523.
[29] Y. Zhang, D.G. Xia, Q.L. Zhao, G.Z. Zhang, Y.S. Zhang, Z.Y. Qiu, D.X. Shen, C. Lu, Label-free proteomic analysis of silkworm midgut infected by Bombyx mori nuclear polyhedrosis virus, J Proteomics, 200 (2019) 40-50.
[30] Yanwei Li, Liang Yao, Liwei Zhang, Yeshun Zhang, Tao Zheng, Lei Liu, Lei Zhang. Enhanced physicochemical stabilities of cyanidin-3-O-glucoside via combination with silk fibroin peptide, Food Chemistry 355 (2021) 129479
[31] Y.K. Li, Y. Huang, P. Pan, X. Che, Y.R. Zhang, Y.S. Zhang, A. Amal, X. Li, W.J. Niu, N.C. Luo, W. Zhang, D.L. Gao, Q.P. Tan, Q.W. Zhang, X.W. Xing, Z. Luo, J.G. Wu, Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response, Appl Mater Today 25 (2021)
[32]Dingguo Xia，Yadong Wei, Guozheng Zhang，Qiaoling Zhao，Yeshun Zhang, Zhonghuai Xiang，Cheng Lu. cDNA cloning, expression, and enzymatic activity of a novel endogenous cellulase from the beetle Batocera horsfieldi,GENE, 2013,514 (1) :62-68.
Book:
Guozhong Lv, Yingjun Guo, Xue chen, Yeshun Zhang (associate editor).Materials Science for Repairing Skin and Soft Tissue Injuries in China,Zhengzhou University Press, 2024.
乔晓月, 曹喜涛, 季更生, 屠洁, 李强, 张业顺, 张国政. 一种白黎芦醇丝素蛋白包埋物及其制备方法和在黄酒中制备中的应用(201811407162.1)
王琳,王征,张业顺,刘佳,黄雷,乞超,徐鲁明,宋煜,杨文,谢洪建,王健,张诚.一种丝胶蛋白-海藻酸盐复合水凝胶及其制备方法(ZL 201510097717.7)
王琳,张业顺,黄雷,刘佳,王征,李永奎,杨文,乞超.丝胶蛋白水凝胶的制备方法及其应用(ZL 201410071402.0)
陆莹霞,张业顺,张国政,李聪,张议文,方梦莹,曹喜涛,凌敏.史紫凌.蚕丝蛋白创伤敷料及其制备方法和应用(201811249902.3)
杨洁,陆莹霞,江茹兰,张业顺,张国政,张议文,方梦莹,凌敏,史紫凌,李聪.功能性丝胶蛋白水凝胶及其制备方法和应用(201910194404.1)
张国政,张业顺,方瑷,吴堂凤,梁培生,李思儒,何小柏,夏定国,布塔库孜.木拉提别克.一种蚕丝蛋白生物支架及其制备方法和应用（ZL 201710564056.3）
张业顺,张国政,熊晓东,戴争妍,方瑷,吴堂凤,李木旺,梁培生.一种丝胶蛋白水凝胶及其制备方法和应用( ZL201710981720.4)
张业顺,张国政,方瑷,吴堂凤,陆莹霞,李木旺,梁培生,何小柏,李聪,一种丝胶蛋白创伤敷料及其制备方法和应用（ZL 201710564058.2）
张业顺, 张国政, 陈和光, 方瑷 , 吴堂凤 , 梁培生 , 夏定国 , 何小柏，高机械强度丝胶蛋白水凝胶及其制备方法和应用（201911086861.5）
张业顺 ,沈聪昳, 张国政, 吴堂凤, 钱平, 朱大林, 方瑷, 曹喜涛, 冉素晴. 一种丝胶蛋白水凝胶及其制备方法和应用（202011442869.3）
获奖
1. 第九届全国大学生生命科学竞赛二等奖（项目：丝路领航-丝胶蛋白无血清培养基研发及产业化），指导教师，2024年；
2. 第八届全国生命科学大赛一等奖（项目：鸾凤丝胶——丝胶蛋白新材料研发及产业化），指导教师，2023年；
3. 校优秀硕士论文，指导教师，2023；
4. 全国生命科学大赛三等奖，指导教师，2021年；
5. Best Researcher award, 4 th Edition of International Research Awards on Advanced Nanomaterials and Nanotechnology，2023年；
6. 江苏科技大学2019-2020学年教学优秀奖 (2020年)
7. “蚕丝蛋白生物医用材料的开发及应用”获全省高校、科研院所教职工优秀创新成果奖（第一完成人，2020年）
8. 江苏科技大学优秀教师(2020年)
9. 江苏科技大学本科生创新创业训练计划优秀指导教师 (2020年)
10. “蚕丝蛋白及其应用技术”成果入选首届全国农业科技成果转化大会1000 项优秀农业科技成果(2019年)
11. “新型促皮肤损伤修复蚕丝蛋白敷料的研制”获得16届大学生挑战杯竞赛全国三等奖和江苏省决赛一等奖(指导教师, 2...
12.“不同品种丝胶蛋白替代胎牛血清培养细胞的研究”获江苏科技大学优秀毕业论文(指导教师,2019年)
13.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市第12届哲学社会科学三等奖(第一完成人,2018年)
14.“一带一路”和“大运河”文化带建设背景下镇江蚕桑文化保护与发展策略研究”获镇江市社科应用精品工程二等奖(第二完成人,2018年)
15.“镇江大运河文化带开发与利用研究”获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
16.“大运河镇江段文化遗产的保护与发展策略研究获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
17.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市教育专项研究一等奖1项（第一完成人，2017年）
#为共一，*为通信作者
Paper:
[1] Zilong Gao, Xiang Li, Yiqing Jiang, Beihui Lu, Guozheng Zhang, Wengong Huang , Yurong Li, Yeshun Zhang*. Bioactive hydrogel dressing with inherent antimicrobial and antioxidant activity for wound healing, Biomacromolecules, 2025, 26 (9), 6091–6103.
[2]Limin Bai, Chuheng Guo, Siwei Cao, Xiaowei Zhang, Xiaomei Li, Qiangwei Fang, Yeshun Zhang*, Gang Xu*.A novel injectable Sericin/Nano-hydroxyapatite hydrogel as a dermal filler for soft tissue augmentation.International Journal of Biological Macromolecules, 2025, 320,145814.
[3] Yurong Li#, Yongkang Wei#, Zilong Gao, Guozheng Zhang, Mingkun Zhu, Hui Yan,Yeshun Zhang*. A multifunctional sericin hydrogel system fabricated via one-step acetic acid induction for wound management
[4] Xiang Li, Yurong Li, Akou May Tehoungue, Qianyan Wang, Hui Yan, Guozheng Zhang, Yeshun Zhang*. An antibacterial hydrogel based on silk sericin cross-linking glycyrrhizic acid and silver for infectious wound healing, Biomacromolecules, 2025,26 (4), 2356–2367.
[5] Xingyue Wang#, Susu Wang#, Akoumay Tehoungue , Yurong Li, Xiang Li, Yanhui, Mingkun Zhu, Guozheng Zhang, Yeshun Zhang*. A robust visualized sericin hydrogel dressing with excellent antioxidative and antimicrobial activities facilitates diabetic wound healing. Journal of the Mechanical Behavior of Biomedical Materials, 2025,165, 106927.
[6] Xinyu Cao#, Xinyi Ding#, Rui Chen, Yurong Li, Akoumay Tehoungue, Wengong Huang, Guoping Kang, Guozheng Zhang,Yeshun Zhang*.Explore the antioxidative and tyrosinase inhibitory activity of green sericin resources from different fibroin-deficient silkworm varieties. Journal of Food Measurement and Characterization.2025, 19, 593-602.
[7] Zhanyan Du#, Zhihan Yan#, Yanan Guo#, Ruixi Ye, Akoumay Tehoungue, Yurong Li, Guozheng Zhang, Yeshun Zhang*. A high stretchable, transparent sericin hydrogel with antioxidant activity formed by CaCl2-formic acid dissolution system. Polymer, 2025, 317, 127929.
[8] Yongkang Wei#, Yanwei Li#, Yurong Li, Gang Xu, Tangfeng Wu, Xiang Li, Ruixi Ye, Meilin Xi, Xiaomei Li, Guozheng Zhang, Yeshun Zhang*. Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing. Biomed. Mater. 2024, 19, 035008.
[9] Yeshun Zhang#*, Xinyu Cao#, Jingya Zhang, Guozheng Zhang, Mingkun Zhu, Hui Yan, Yurong Li*. A novel injectable sericin hydrogel with strong fluorescence for tracing. International Journal of Biological Macromolecules, 2023, 258,12900.
[10] Limin Bai, Xiaowei Zhang, Xiaomei Li, Susu Wang, Yeshun Zhang*, Gang Xu*. Impact of a novel hydrogel with injectable platelet-rich fibrin in diabetic wound healing.Journal of Diabetes Research, 2023, 7532637.
[11] Yurong Li#, Yongkang Wei#, Guozheng Zhang, Yeshun Zhang*. Sericin from fibroin-deficient silkworms served as a promising resource for biomedicine, Polymers, 2023,15, 2941.
[12] Ruixi Ye#, Siyu Liu#, Wenkai Zhu#, Yurong Li, Long Huang, Guozheng Zhang, Yeshun Zhang*. Synthesis, characterization, properties, and biomedical application of chitosan-based hydrogels. Polymers 2023, 15, 2482.
[13] Yanwei Li#, Susu Wang#, Yurong Li#, Guozheng Zhang, Tangfeng Wu, Yongkang Wei, Xinyu Cao, Hui Yan, Peisheng Liang, Zihan Yan, Yanan Guo, Yeshun Zhang*. Resveratrol loaded native silk fiber-sericin hydrogel double interpenetrating bioactive wound dressing facilitates full-thickness skin wound healing.Biomed. Mater. 2023, 18, 045007
[14] Yanwei Li#, Tangfeng Wu#, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang*. A native sericin wound dressing spun directly from silkworms enhances，Colloids and Surfaces B: Biointerfaces 2023,225, 113228.
[15] Yeshun Zhang#*, Susu Wang#, Yurong Li, Xiang Li, Zhanyan Du, Siyu Liu, Yushuo Song, Yanyan Li, Guozheng Zhang. A sterile, injectable, and robust sericin hydrogel prepared by degraded sericin. Gels, 2013,9,948.
[16] M. Zhu, M. Yan, J. Chen, H. Li, Y. Zhang* MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H2O2-induced oxidative stress, Poult Sci 102(10) (2023) 103006.
[17] Ziniu Zhao, Yihan Liu, Shuo Yang, Yurong Li, Yeshun Zhang, Hui Yan* Fast detection of the tenderness of mulberry leaves by a portable near-infrared spectrometer with variable selection，Infrared Physics & Technology, 2023, 113,104818.
[18] Yeshun Zhang*, Wu Tangfeng, Congyi Shen, Gang Xu, Heguang Chen, Hui Yan, Meng Xiong, Guozheng Zhang*. A robust sericin hydrogel formed by a native sericin from silkworm bodies, Fibers and polymers, 2022
[19] Yeshun Zhang#, Heguang Chen#, Yulin Li, Ai Fang, Tangfeng Wu, Congyi Shen, Yuying Zhao, Guozheng Zhang*, A transparent sericin-polyacrylamide interpenetrating network hydrogel as visualized dressing material, Polymer testing, 2020,87, 106517
[20] Yeshun Zhang#，Rulan Jiang#, Ai Fang, Yuying Zhao, Tangfeng Wu, Xitao Cao, Peisheng Liang, Dingguo Xia, Guozheng Zhang*. A highly transparent, elastic, injectable sericin hydrogel induced by ultrasound, Polymer testing, 2019, 77:105890.
[21] Yeshun Zhang#，Yuying Zhao#, Xiaobai He, Ai Fang, RulanJiang, Tangfeng Wu, Heguang Chen, XitaoCao, Peisheng Liang, DingguoXia, Guozheng Zhang*. A sterile self-assembled sericin hydrogel via a simple two-step process, Polymer testing, 2019, 80:106016.
[22] Yeshun Zhang, Jia Liu, Lei Huang, Zheng Wang, Lin Wang*. Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery. Scientific Reports, doi:10.1038/srep12374, 2015.
[23] Zheng Wang#, Yeshun Zhang#, Jinxiang Zhang, Lei Huang, Jia Liu, Yongkui Li, Guozheng Zhang, Subhas C. Kundu, Lin Wang*. Exploring natural silk protein sericin for regenerative medicine: an injectable, photoluminescent, cell-adhesive 3D hydrogel. Scientific Reports, doi:10.1038/srep07064, 2014.
[24] Wanpeng Liu, Zhitao Zhou, Shaoqing Zhang, Zhifeng Shi, Justin Tabarini, Woonsoo Lee, Yeshun Zhang, S. N. Gilbert Corder, Xinxin Li, Fei Dong, Liang Cheng,Mengkun Liu, David L. Kaplan, Fiorenzo G. Omenetto, Guozheng Zhang,* Ying Mao,*and Tiger H. Tao* Precise protein photolithography (p3): high performance biopatterning using silk fibroin light chain as the resist，Adv. Sci. 2017, 4:1700191.
[25] Zhitao Zhou，Zhifeng Shi，Xiaoqing Cai，Shaoqing Zhang，Stephanie G. Corder， Xinxin Li，Yeshun Zhang，Guozheng Zhang，Liang Chen，Mengkun Liu，David L. Kaplan，Fiorenzo G. Omenetto，Ying Mao，Zhendong Tao，Tiger H.Tao，The use of functionalized silk fibroin films as a platform for optical diffraction-based sensing applications，Advanced materials，2017.2.13.
[26] Changsheng Chen, Fei Zeng, Xiao Xiao, Zhen Wang, Xiaoli Li, Weirong Tan, Weiqiang Liu, Yeshun Zhang, Zhending She, Songjian Li Three-dimensionally printed silk-sericin-based hydrogel scaffold: a promising visualized dressing material for real-time monitoring of wounds. ACS Appl Mater Interfaces. 2018,10 (40):33879-33890.
[27] Keyin Liu, Zhifeng Shi, Shaoqing Zhang, Zhitao Zhou, Long Sun, Tao Xu, Yeshun Zhang, Guozheng Zhang, Xinxin Li, Liang Chen, Ying Mao, Tiger H. Tao. A silk cranial fixation system for neurosurgery, Advanced healthcare materials, 2018,1701359.
[28] X. Xiao, C.S. Chen, W.Q. Liu, Y.S. Zhang, Structure, features and biomedical applications of silk sericin, Prog Chem, 29 (2017) 513-523.
[29] Y. Zhang, D.G. Xia, Q.L. Zhao, G.Z. Zhang, Y.S. Zhang, Z.Y. Qiu, D.X. Shen, C. Lu, Label-free proteomic analysis of silkworm midgut infected by Bombyx mori nuclear polyhedrosis virus, J Proteomics, 200 (2019) 40-50.
[30] Yanwei Li, Liang Yao, Liwei Zhang, Yeshun Zhang, Tao Zheng, Lei Liu, Lei Zhang. Enhanced physicochemical stabilities of cyanidin-3-O-glucoside via combination with silk fibroin peptide, Food Chemistry 355 (2021) 129479
[31] Y.K. Li, Y. Huang, P. Pan, X. Che, Y.R. Zhang, Y.S. Zhang, A. Amal, X. Li, W.J. Niu, N.C. Luo, W. Zhang, D.L. Gao, Q.P. Tan, Q.W. Zhang, X.W. Xing, Z. Luo, J.G. Wu, Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response, Appl Mater Today 25 (2021)
[32]Dingguo Xia，Yadong Wei, Guozheng Zhang，Qiaoling Zhao，Yeshun Zhang, Zhonghuai Xiang，Cheng Lu. cDNA cloning, expression, and enzymatic activity of a novel endogenous cellulase from the beetle Batocera horsfieldi,GENE, 2013,514 (1) :62-68.
Book:
Guozhong Lv, Yingjun Guo, Xue chen, Yeshun Zhang (associate editor).Materials Science for Repairing Skin and Soft Tissue Injuries in China,Zhengzhou University Press, 2024.
乔晓月, 曹喜涛, 季更生, 屠洁, 李强, 张业顺, 张国政. 一种白黎芦醇丝素蛋白包埋物及其制备方法和在黄酒中制备中的应用(201811407162.1)
王琳,王征,张业顺,刘佳,黄雷,乞超,徐鲁明,宋煜,杨文,谢洪建,王健,张诚.一种丝胶蛋白-海藻酸盐复合水凝胶及其制备方法(ZL 201510097717.7)
王琳,张业顺,黄雷,刘佳,王征,李永奎,杨文,乞超.丝胶蛋白水凝胶的制备方法及其应用(ZL 201410071402.0)
陆莹霞,张业顺,张国政,李聪,张议文,方梦莹,曹喜涛,凌敏.史紫凌.蚕丝蛋白创伤敷料及其制备方法和应用(201811249902.3)
杨洁,陆莹霞,江茹兰,张业顺,张国政,张议文,方梦莹,凌敏,史紫凌,李聪.功能性丝胶蛋白水凝胶及其制备方法和应用(201910194404.1)
张国政,张业顺,方瑷,吴堂凤,梁培生,李思儒,何小柏,夏定国,布塔库孜.木拉提别克.一种蚕丝蛋白生物支架及其制备方法和应用（ZL 201710564056.3）
张业顺,张国政,熊晓东,戴争妍,方瑷,吴堂凤,李木旺,梁培生.一种丝胶蛋白水凝胶及其制备方法和应用( ZL201710981720.4)
张业顺,张国政,方瑷,吴堂凤,陆莹霞,李木旺,梁培生,何小柏,李聪,一种丝胶蛋白创伤敷料及其制备方法和应用（ZL 201710564058.2）
张业顺, 张国政, 陈和光, 方瑷 , 吴堂凤 , 梁培生 , 夏定国 , 何小柏，高机械强度丝胶蛋白水凝胶及其制备方法和应用（201911086861.5）
张业顺 ,沈聪昳, 张国政, 吴堂凤, 钱平, 朱大林, 方瑷, 曹喜涛, 冉素晴. 一种丝胶蛋白水凝胶及其制备方法和应用（202011442869.3）
获奖
1. 第九届全国大学生生命科学竞赛二等奖（项目：丝路领航-丝胶蛋白无血清培养基研发及产业化），指导教师，2024年；
2. 第八届全国生命科学大赛一等奖（项目：鸾凤丝胶——丝胶蛋白新材料研发及产业化），指导教师，2023年；
3. 校优秀硕士论文，指导教师，2023；
4. 全国生命科学大赛三等奖，指导教师，2021年；
5. Best Researcher award, 4 th Edition of International Research Awards on Advanced Nanomaterials and Nanotechnology，2023年；
6. 江苏科技大学2019-2020学年教学优秀奖 (2020年)
7. “蚕丝蛋白生物医用材料的开发及应用”获全省高校、科研院所教职工优秀创新成果奖（第一完成人，2020年）
8. 江苏科技大学优秀教师(2020年)
9. 江苏科技大学本科生创新创业训练计划优秀指导教师 (2020年)
10. “蚕丝蛋白及其应用技术”成果入选首届全国农业科技成果转化大会1000 项优秀农业科技成果(2019年)
11. “新型促皮肤损伤修复蚕丝蛋白敷料的研制”获得16届大学生挑战杯竞赛全国三等奖和江苏省决赛一等奖(指导教师, 2...
12.“不同品种丝胶蛋白替代胎牛血清培养细胞的研究”获江苏科技大学优秀毕业论文(指导教师,2019年)
13.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市第12届哲学社会科学三等奖(第一完成人,2018年)
14.“一带一路”和“大运河”文化带建设背景下镇江蚕桑文化保护与发展策略研究”获镇江市社科应用精品工程二等奖(第二完成人,2018年)
15.“镇江大运河文化带开发与利用研究”获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
16.“大运河镇江段文化遗产的保护与发展策略研究获镇江市社科应用研究精品工程三等奖(第二完成人,2018年)
17.“一带一路”战略下镇江蚕桑文化教育的现状与对策研究”获镇江市教育专项研究一等奖1项（第一完成人，2017年）
工学博士, 2012.09～2015.06，华中科技大学（生物医学工程专业）
农学硕士, 2004.09～2007.06，江苏科技大学（特种经济动物饲养专业）
农学学士, 2000.09～2004.07，安徽科技学院（动物科学专业）
高中, 1997.09～2000.06，安徽省颍上县第一中学
本科生课程：《生物材料学》；《生物工程导论》
研究生课程：《生物材料与组织工程》
开放选修课程:《生物材料与组织工程学开放选修实验》
学校地址：江苏省镇江市丹徒区长晖路666号
邮编：212100
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