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陈孝云 副教授

环境与化学工程学院

通讯地址：江苏省镇江市梦溪路2号

个人邮箱：chenxy@just.edu.cn

邮政编码：212003

办公地点：Changhui Road N

传真：

  • 个人简介

  • 科研团队

  • 获奖动态

  • 教学随笔

  • 教育经历

  • 课程教学

  • 论文著作

  • 科研论文

  • 科研横向项目

  • 科研纵向项目

  • 科研专利

  • 科研动物专利

  • 本人主要从事新型功能小分子的合成研究及新反应方法的建立这三方面的工作。工作主要集中在：

    1）开发新的方法和新的试剂以合成烯胺类分子并实现烯胺的β功能化；

    2）利用开发的新反应方法制备相应的生物活性小分子并完成后期的活性测试等相关工作；

    3）新的活体内小分子双光子光敏基团和探针的合成。

        运用已有的方法合成新的功能分子，总会遇到众多阻力，为了克服这类合成阻力，需要发展新的合成方法。在实际需要的前提下，发展了一系列新的反应方法以制备相应的功能小分子，特别是烯胺类化合物。并将该类分子应用于相应地杀虫杀菌活性分子及功能材料的制备中，促进产-学-研结合和不同领域的相互交叉 ，在烯胺领域更好地实现科研和应用的结合。


    • 专利成果

      授权专利：

      [1].陈孝云，袁书侠，汤耀南，孙晨阳，陈研，陈凯伟，陈光，朱宝成. 一种β-卤代烯胺酸酯化合物及其制备方法（发明），专利申请号: 202010291109.0;

      [2].陈孝云，汤耀南，陈研 , 孙晨阳 , 唐毅松. 一种一步法制备三取代吲哚化合物的方法（发明），专利申请号: 202110422997.X;

      [3].陈孝云, 汤耀南, 孙晨阳, 陈妍, 唐毅松. 一种亚砜亚胺烯胺酸酯化合物及其准备方法（发明），专利号：202110629783.X；

      [4].陈孝云, 陈研, 孙晨阳, 张晓彤, 朱瑞, 郑绍军. 一种新型的氰基炔烃类化合物的制备方法（发明）, 申请号: 202210276062.X.

      [5].陈孝云,李晓倩, 李吉, 向毅, 黄华, 蔡雨田, 周玉洁, 郑绍军, 陈磊, 杨亦谋, 朱瑞. 一种烟碱与吲哚类杂化化合物、其合成方法及其用途（发明），申请号: 202111411993.8.



      申请专利：

      [1].陈孝云, 唐毅松, 张晓彤, 黄名扬, 齐广杰, 项欣然. 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法（PCT），专利申请号: PCT/CN2022/124661；

      [2].陈孝云, 唐毅松, 张晓彤, 朱瑞, 郑绍军. 一种有机燃料催化合成β-三氟甲基烯胺化合物的方法（发明），专利申请号: 202211038882.1；

      [3].项欣然, 孙晨阳, 陈孝云. 一种基于喹啉设计的过氧化氢小分子荧光探针及其制备方法, 专利申请号: 202211045905.1;

      [4].陈孝云, 唐毅松, 张晓彤, 项欣然. 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法 , 申请号: 202210741658.2;

      [5].陈孝云, 陈研, 孙晨阳, 张晓彤, 朱瑞, 郑绍军. 一种新型的氰基炔烃类化合物的制备方法, 申请号: 202210276062.X.


    • 论文著作

      [1]Jiang, L.; Tang, Y.; Li, S.; Peng, X.; Saffar Andaloussi, R.; Chen, X. Y.*, Visible Light-Driven Metal- and Photocatalyst-Free Synthesis of β-Trifluoromethylated Enamines via Trifluoromethyl Thianthrenium Salts. Chem. Asian J., 2025, 20, e202401129; 


      [2] Tang, Y.; Jiang, L.; Li, S.; Chen, X. Y.*; Li, C.; Zhang, X., Iodine-promoted for synthesis of (Z)-β-dithiocarbamate enamine derivatives in water and their antibacterial evaluation. J. Mol. Struct. 2025, 1322, 140356;


      [3] Tang, Y.; Cai, Y.; Xie, Z.; Gao, Z.; Chen, X. Y.*; Yi, J.*, Multicomponent reactions to access S-aryl dithiocarbamates via an electron donor–acceptor complex under open-to-air conditions. Org. Biomol. Chem. 2024, 22, 1378-1385;


      [4] Tang, Y.; Huang, M.; Jiang, L.; Zhang, X.; Zheng, S.; Yang, Y.; Chen, X. Y.*, Visible‐Light Irradiated Multicomponent Reactions of Aliphatic Amines, Propiolate Acid Esters and CF3SO2Na for Accessing β‐CF3 Enamines. Chem. Eur. J 2023, n/a, e202302249.

        

      [5] Chen, X. Y.*; Tang, Y.; Xiang, X.; Tang, Y.; Huang, M.; Zheng, S.; Yang, C., Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-Dibromo Indoles Using N-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents. Molecules 2023, 28, 3380.

        

      [6] Tang, Y.; Tang, Y.; zhu, R.; Zheng, S.; Cheng, X.; Chen, X. Y.*, Metal-free synthesis of N-vinyl sulfoximines via DABCO-participated Michael addition of terminal carbonyl alkynes with N-chlorosulfoximines. Tetrahedron 2022, 129, 133142.

        

      [7] Chen, X. Y.*; Zhang, X.; Wan, J.-P., Recent advances in transition metal-free annulation toward heterocycle diversity based on the C–N bond cleavage of enaminone platform. Org. Biomol. Chem. 2022, 20, 2356-2369.

        

      [8] Chen, X. Y.*; Yuan, S.; Chen, Y.; Sun, C.; Tang, Y.; Chen, G.; Zhu, B.; Chen, K.; Zheng, S.; Cheng, X., Solvent-controlled two-step one-pot syntheses of α-X (X = Br or Cl) enamino ketones/esters and 3-(2,5-dioxopyrrolidin-1-yl)acrylate by using terminal carbonyl alkynes. Org. Biomol. Chem. 2021, 19, 7914-7919.

        

      [9] Chen, X. Y.*; Zhang, L.; Tang, Y.; Yuan, S.; Zhu, B.; Chen, G.; Cheng, X., Green H2O-Promoted Solvent-Free Synthesis of Enaminocarbonyl Compounds with High Stereoselectivity from Electron-Deficient Terminal Alkynes. Synlett 2020, 31, 878-882.

        

      [10] Chen, X. Y.*, Deng. X., Tang Y.,Yuan M.,Yuan, S., Study on reactive fluorescein-based TPA type Cu+probes. Journal of Jiangsu University of Science and Technology( Natural Science Edition) 2020, 34, 88-95.

        

      [11] Hou, H.*; Tang, D.; Li, H.; Xu, Y.; Yan, C.; Shi, Y.; Chen, X. Y.*; Zhu, S.*, Visible-Light-Driven Chlorotrifluoromethylative and Chlorotrichloromethylative Cyclizations of Enynes. J. Org. Chem. 2019,84 (11), 7509

        

      [12] Wu, H.-Q.; Yang, K.; Chen, X. Y.*; Arulkumar, M.; Wang, N.; Chen, S.-H.; Wang, Z.-Y.*, A 3,4-dihalo-2(5H)-furanone initiated ring-opening reaction of DABCO in the absence of a metal catalyst and additive and its application in a one-pot two-step reaction. Green Chem. 2019,21 (14), 3782.

        

      [13] Yang, K.; Gao, J. J.; Luo, S. H.*; Wu, H. Q.; Pang, C. M.; Wang, B. W.; Chen, X. Y.*; Wang, Z. Y., Quick construction of a C-N bond from arylsulfonyl hydrazides and C-sp2-X compounds promoted by DMAP at room temperature. RSC Adv. 2019,9 (35), 19917；

        

      [14] Yuan, M.; Chen, X. Y.*;  Lin, S.*, Synthesis of the Functionalized Enamine. Prog. Chem. 2018,30 (8), 1082.

        

      [15] Steinkamp, A.-D.; Schmitt, L.; Chen, X. Y; Fietkau, K.; Heise, R.; Baron, J. M.; Bolm, C. Synthesis of a sulfonimidamide-based analog of tasisulam and its biological evaluation in the melanoma cell lines SKMel23 and A375.Skin Pharmacol Physiol. 2016, 29, 281.

        

      [16] Chen, X. Y.; Englert, U.; Bolm, C. Base-Mediated Syntheses of Di- and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes, Chem. Eur. J.2015, 21, 13221.

        

      [17] Chen, X. Y.; Bohmann, R. A.; Wang, L.; Dong, S. X.; Raeuber, C,;Bolm, C. Palladium/Copper-Cocatalyzed Oxidative Amido-brominations of Alkenes.Chem. Eur. J.2015, 21, 10330.

        

      [18] Chen, X. Y.; Wang, L.; Frings, M.; Bolm, C. Copper-Catalyzed N-Alkynylation of Sulfoximines with Bromoacetylenes. Org. Lett., 2014, 16, 3796.

        

      [19] Chen, X. Y.; Buschmann, H.; Bolm, C. Sulfoximine- and Sulfilimine-Based DAPSON Analogs: Syntheses and Bioactivities.Synlett.2012,23, 2808.

        

      [20] Chen, X. Y.; Park, S. J.; Buschmann, H.; De Rosa, M.; Bolm, C. Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins. Bioorg. Med. Chem. Lett.2012, 22, 4307.（

        

      [21] Chen, X. Y.; Shi, J.; Li, Y. M.; Wang, F. L.; Wu, X.; Guo, Q. X.; Liu, L. Two-Photon Fluorescent Probes of Biological Zn(II) Derived from 7-Hydroxyquinoline. Org. Lett.2009, 11, 4426.

        

      [22] 陈孝云，刘磊：《桧山偶联反应》，现代有机反应(第6卷金属催化反应Ⅱ)，胡跃飞，林国强编，ISBN：9787122145987, 化学工业出版社, 2013, 85.

        

      [23] Shi, J.; Tang, X. D.; Wu, Y. C.; Fang, J. F.; Cao, L.; Chen, X. Y. *; Wang, Z.-Y. *A radical coupling reaction of DMSO with sodium arylsulfinates in air: mild utilization of DMSO as C1 resource for the synthesis of arylsulfonyl dibromomethane, RSC Adv., 2016, 6, 25651.

        

      [24] Xiong, J. F.; Li, J. X.; Mo, G. Z.; Huo, J. P.; Liu, J. Y.;Chen, X. Y.*; Wang, Z. Y.*Benzimidazole derivatives: Selective fluorescent chemosensor for the picogram detection of picric acid. J. Org. Chem. 2014, 79, 11619.

        

      [25] Peng, P.;Xiong, J. F.; Mo, G. Z.; Zheng, J. L.; Chen, R. H.; Chen, X. Y.*; Wang, Z. Y.*A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale. Amino Acids, 2014, 46, 2427.

        

  • 理学博士, 09/2010～12/2014，德国亚琛工业大学（RWTH-Aachen university，Carsten Bolm教授, 有机化学专业）

    理学硕士, 09/2007～06/2010，中国科学技术大学（郭庆祥教授，有机化学专业）

    理学学士，09/2000～06/2004，华南师范大学（化学专业）


  • 学年

    课程名称

    课程性质

    授课对象

    课时数

    2015-2016-1

    大学化学

    基础课

    本科生

    32

    2015-2018

    （共3学年）

    精细有机合成及单元反应

    专业课

    本科生

    32

    2015-2016-2

    绿色化学

    选修课

    研究生

    32

    2016-2017-1

    普通化学

    基础课

    本科生

    32

    2019-2024

    （共6学年）

    		合成及单元反应专业课本科生32

    2019-2024

    （共5学年）

    		现代有机合成专业课留学生48

    2019-2024

    （共5学年）

    		高等有机化学专业课留学生16

    2019-2024

    （共5学年）

    		精细有机合成选修课留学生24

    2021-2024

    （共3学年）

    		有机化学基础课本科生40

    2017-2024

    （共7学年）

    		现代有机合成选修课研究生32



    • 专利成果

      授权专利：

      [1].陈孝云，袁书侠，汤耀南，孙晨阳，陈研，陈凯伟，陈光，朱宝成. 一种β-卤代烯胺酸酯化合物及其制备方法（发明），专利申请号: 202010291109.0;

      [2].陈孝云，汤耀南，陈研 , 孙晨阳 , 唐毅松. 一种一步法制备三取代吲哚化合物的方法（发明），专利申请号: 202110422997.X;

      [3].陈孝云, 汤耀南, 孙晨阳, 陈妍, 唐毅松. 一种亚砜亚胺烯胺酸酯化合物及其准备方法（发明），专利号：202110629783.X；

      [4].陈孝云, 陈研, 孙晨阳, 张晓彤, 朱瑞, 郑绍军. 一种新型的氰基炔烃类化合物的制备方法（发明）, 申请号: 202210276062.X.

      [5].陈孝云,李晓倩, 李吉, 向毅, 黄华, 蔡雨田, 周玉洁, 郑绍军, 陈磊, 杨亦谋, 朱瑞. 一种烟碱与吲哚类杂化化合物、其合成方法及其用途（发明），申请号: 202111411993.8.



      申请专利：

      [1].陈孝云, 唐毅松, 张晓彤, 黄名扬, 齐广杰, 项欣然. 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法（PCT），专利申请号: PCT/CN2022/124661；

      [2].陈孝云, 唐毅松, 张晓彤, 朱瑞, 郑绍军. 一种有机燃料催化合成β-三氟甲基烯胺化合物的方法（发明），专利申请号: 202211038882.1；

      [3].项欣然, 孙晨阳, 陈孝云. 一种基于喹啉设计的过氧化氢小分子荧光探针及其制备方法, 专利申请号: 202211045905.1;

      [4].陈孝云, 唐毅松, 张晓彤, 项欣然. 一种基于有机染料催化的β-三氟甲基烯胺化合物的制备方法 , 申请号: 202210741658.2;

      [5].陈孝云, 陈研, 孙晨阳, 张晓彤, 朱瑞, 郑绍军. 一种新型的氰基炔烃类化合物的制备方法, 申请号: 202210276062.X.


    • 论文著作

      [1]Jiang, L.; Tang, Y.; Li, S.; Peng, X.; Saffar Andaloussi, R.; Chen, X. Y.*, Visible Light-Driven Metal- and Photocatalyst-Free Synthesis of β-Trifluoromethylated Enamines via Trifluoromethyl Thianthrenium Salts. Chem. Asian J., 2025, 20, e202401129; 


      [2] Tang, Y.; Jiang, L.; Li, S.; Chen, X. Y.*; Li, C.; Zhang, X., Iodine-promoted for synthesis of (Z)-β-dithiocarbamate enamine derivatives in water and their antibacterial evaluation. J. Mol. Struct. 2025, 1322, 140356;


      [3] Tang, Y.; Cai, Y.; Xie, Z.; Gao, Z.; Chen, X. Y.*; Yi, J.*, Multicomponent reactions to access S-aryl dithiocarbamates via an electron donor–acceptor complex under open-to-air conditions. Org. Biomol. Chem. 2024, 22, 1378-1385;


      [4] Tang, Y.; Huang, M.; Jiang, L.; Zhang, X.; Zheng, S.; Yang, Y.; Chen, X. Y.*, Visible‐Light Irradiated Multicomponent Reactions of Aliphatic Amines, Propiolate Acid Esters and CF3SO2Na for Accessing β‐CF3 Enamines. Chem. Eur. J 2023, n/a, e202302249.

        

      [5] Chen, X. Y.*; Tang, Y.; Xiang, X.; Tang, Y.; Huang, M.; Zheng, S.; Yang, C., Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-Dibromo Indoles Using N-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents. Molecules 2023, 28, 3380.

        

      [6] Tang, Y.; Tang, Y.; zhu, R.; Zheng, S.; Cheng, X.; Chen, X. Y.*, Metal-free synthesis of N-vinyl sulfoximines via DABCO-participated Michael addition of terminal carbonyl alkynes with N-chlorosulfoximines. Tetrahedron 2022, 129, 133142.

        

      [7] Chen, X. Y.*; Zhang, X.; Wan, J.-P., Recent advances in transition metal-free annulation toward heterocycle diversity based on the C–N bond cleavage of enaminone platform. Org. Biomol. Chem. 2022, 20, 2356-2369.

        

      [8] Chen, X. Y.*; Yuan, S.; Chen, Y.; Sun, C.; Tang, Y.; Chen, G.; Zhu, B.; Chen, K.; Zheng, S.; Cheng, X., Solvent-controlled two-step one-pot syntheses of α-X (X = Br or Cl) enamino ketones/esters and 3-(2,5-dioxopyrrolidin-1-yl)acrylate by using terminal carbonyl alkynes. Org. Biomol. Chem. 2021, 19, 7914-7919.

        

      [9] Chen, X. Y.*; Zhang, L.; Tang, Y.; Yuan, S.; Zhu, B.; Chen, G.; Cheng, X., Green H2O-Promoted Solvent-Free Synthesis of Enaminocarbonyl Compounds with High Stereoselectivity from Electron-Deficient Terminal Alkynes. Synlett 2020, 31, 878-882.

        

      [10] Chen, X. Y.*, Deng. X., Tang Y.,Yuan M.,Yuan, S., Study on reactive fluorescein-based TPA type Cu+probes. Journal of Jiangsu University of Science and Technology( Natural Science Edition) 2020, 34, 88-95.

        

      [11] Hou, H.*; Tang, D.; Li, H.; Xu, Y.; Yan, C.; Shi, Y.; Chen, X. Y.*; Zhu, S.*, Visible-Light-Driven Chlorotrifluoromethylative and Chlorotrichloromethylative Cyclizations of Enynes. J. Org. Chem. 2019,84 (11), 7509

        

      [12] Wu, H.-Q.; Yang, K.; Chen, X. Y.*; Arulkumar, M.; Wang, N.; Chen, S.-H.; Wang, Z.-Y.*, A 3,4-dihalo-2(5H)-furanone initiated ring-opening reaction of DABCO in the absence of a metal catalyst and additive and its application in a one-pot two-step reaction. Green Chem. 2019,21 (14), 3782.

        

      [13] Yang, K.; Gao, J. J.; Luo, S. H.*; Wu, H. Q.; Pang, C. M.; Wang, B. W.; Chen, X. Y.*; Wang, Z. Y., Quick construction of a C-N bond from arylsulfonyl hydrazides and C-sp2-X compounds promoted by DMAP at room temperature. RSC Adv. 2019,9 (35), 19917；

        

      [14] Yuan, M.; Chen, X. Y.*;  Lin, S.*, Synthesis of the Functionalized Enamine. Prog. Chem. 2018,30 (8), 1082.

        

      [15] Steinkamp, A.-D.; Schmitt, L.; Chen, X. Y; Fietkau, K.; Heise, R.; Baron, J. M.; Bolm, C. Synthesis of a sulfonimidamide-based analog of tasisulam and its biological evaluation in the melanoma cell lines SKMel23 and A375.Skin Pharmacol Physiol. 2016, 29, 281.

        

      [16] Chen, X. Y.; Englert, U.; Bolm, C. Base-Mediated Syntheses of Di- and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes, Chem. Eur. J.2015, 21, 13221.

        

      [17] Chen, X. Y.; Bohmann, R. A.; Wang, L.; Dong, S. X.; Raeuber, C,;Bolm, C. Palladium/Copper-Cocatalyzed Oxidative Amido-brominations of Alkenes.Chem. Eur. J.2015, 21, 10330.

        

      [18] Chen, X. Y.; Wang, L.; Frings, M.; Bolm, C. Copper-Catalyzed N-Alkynylation of Sulfoximines with Bromoacetylenes. Org. Lett., 2014, 16, 3796.

        

      [19] Chen, X. Y.; Buschmann, H.; Bolm, C. Sulfoximine- and Sulfilimine-Based DAPSON Analogs: Syntheses and Bioactivities.Synlett.2012,23, 2808.

        

      [20] Chen, X. Y.; Park, S. J.; Buschmann, H.; De Rosa, M.; Bolm, C. Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins. Bioorg. Med. Chem. Lett.2012, 22, 4307.（

        

      [21] Chen, X. Y.; Shi, J.; Li, Y. M.; Wang, F. L.; Wu, X.; Guo, Q. X.; Liu, L. Two-Photon Fluorescent Probes of Biological Zn(II) Derived from 7-Hydroxyquinoline. Org. Lett.2009, 11, 4426.

        

      [22] 陈孝云，刘磊：《桧山偶联反应》，现代有机反应(第6卷金属催化反应Ⅱ)，胡跃飞，林国强编，ISBN：9787122145987, 化学工业出版社, 2013, 85.

        

      [23] Shi, J.; Tang, X. D.; Wu, Y. C.; Fang, J. F.; Cao, L.; Chen, X. Y. *; Wang, Z.-Y. *A radical coupling reaction of DMSO with sodium arylsulfinates in air: mild utilization of DMSO as C1 resource for the synthesis of arylsulfonyl dibromomethane, RSC Adv., 2016, 6, 25651.

        

      [24] Xiong, J. F.; Li, J. X.; Mo, G. Z.; Huo, J. P.; Liu, J. Y.;Chen, X. Y.*; Wang, Z. Y.*Benzimidazole derivatives: Selective fluorescent chemosensor for the picogram detection of picric acid. J. Org. Chem. 2014, 79, 11619.

        

      [25] Peng, P.;Xiong, J. F.; Mo, G. Z.; Zheng, J. L.; Chen, R. H.; Chen, X. Y.*; Wang, Z. Y.*A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale. Amino Acids, 2014, 46, 2427.