Abstract: Structural topology and loading condition have important influences on the mechanical behaviors of porous soft solids. The porous solids are usually set to be under uniaxial tension o compression. Only a few studies have considered the biaxial loads, especially the combined loads of tension and compression. In this study, porous soft solids with oblique and square lattices of circular voids under biaxial loadings were studied through integrated experiments and numerical simulations. For the soft solids with oblique lattices of circular voids, we found a new pattern transformation under biaxial compression, which has alternating elliptic voids with an inclined angle. This kind of pattern transformation is rarely reported under uniaxial compression. Introducing tensile deformation in one direction can hamper this kind of pattern transformation under biaxial loading. For the soft solids with square lattices of voids, the number of voids cannot change their deformation behaviors qualitatively, but quantitatively. In general, our present results demonstrate that void morphology and biaxial loading can be harnessed to tune the pattern transformations of porous soft solids under large deformation. This discovery offers a new avenue for designing the void morphology of soft solids for controlling their deformation patterns under a specific biaxial stress-state.